IMPROVED GLUCOSE MANAGEMENT THROUGH MODELING OF CIRCADIAN PROFILES

A computer-implemented system (10) and method (20) for managing diabetes with circadian profiles is provided. A plurality of records containing a circadian profile is stored in a database (14). The circadian profile includes meal period categories (53), typical measurements of pre-meal and post-meal self-measured blood glucose occurring over a recent observational time frame, and diabetes medication (55) dosed during each of the meal period categories (53). An executable application (15) is used to model predicted blood glucose levels, including collecting the self-measured blood glucose measurements, determining and visualizing expected blood glucose values (83, 88, 89, 111, 112) and their predicted errors (84), propagating a suggested incremental change in dosing of the medication (55), and adjusting the visualized expected blood glucose values (83, 88, 89, 111, 112) and their predicted errors based on pharmacodynamics of the medication (55) in proportion to the incremental change in dosing.