DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS

Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5,...

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Bibliographische Detailangaben
Hauptverfasser:	CISKE, FRED LAWRENCE, COLOMBO, JOSEPH MICHAEL, ENDRES, GREGORY WILLIAM, GERMAIN, BRADLEE DAVID, OWEN, THOMAS ALLEN, KRAMER, JAMES BERNARD, UZIEBLO, ADAM, BARRETT, STEPHEN DOUGLAS, KORNILOV, ANDRIY, O'MALLEY, JAMES PAUL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. La présente invention concerne des compositions et des procédés de traitement de l'ostéoporose, d'une fracture osseuse, de la perte osseuse et d'augmentation de la densité osseuse par l'administration de composés de formule (I) ou de compositions comprenant un composé de formule (I) et un support pharmaceutiquement acceptable, L1, L2, L4, R1, R4, R5, R6 et s étant tels que définis dans la description.