POLYMORPHS OF N-[(R)-1-[(S)-1-(4-AMINOMETHYL-BENZYLCARBAMOYL)-2-PHENYL-ETHYLCARBAMOYL]-2-(4-ETHOXY-PHENYL)-ETHYL]-BENZAMIDE HYDROCHLORIDE

POLYMORPHS OF N-[(R)-1-[(S)-1-(4-AMINOMETHYL-BENZYLCARBAMOYL)-2-PHENYL-ETHYLCARBAMOYL]-2-(4-ETHOXY-PHENYL)-ETHYL]-BENZAMIDE HYDROCHLORIDE

The invention provides new polymorphs of N-[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride (Figure A), (see figure A) pharmaceutical compositions containing them and their use in the treatment of a disease or condition mediate...

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Bibliographische Detailangaben
Hauptverfasser: MYKYTIUK, JOHN, NORTHEN, JULIAN SCOTT
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention provides new polymorphs of N-[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride (Figure A), (see figure A) pharmaceutical compositions containing them and their use in the treatment of a disease or condition mediated by plasma kallikrein. L'invention concerne de nouveaux polymorphes d'hydrochlorure de N-[(R)-1-[(S)-1-(4-aminométhyl-benzylcarbamoyl)-2-phényl-éthylcarbamoyl]-2-(4-éthoxy-phényl)-éthyl]-benzamide, des compositions pharmaceutiques les contenant et leur utilisation en thérapie.