TETRAHYDROQUINAZOLINONE DERIVATIVES AS PARP INHIBITORS

Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R1-R6, R7a-d, R8a-d, A, M, n, and p are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, an...

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Bibliographische Detailangaben
Hauptverfasser:	JAGDALE, ARUN RANGNATH, KUKREJA, GAGAN, SINHA, NEELIMA, KAMBOJ, RAJENDER KUMAR, JANA, GOURHARI, PALLE, VENKATA P, KURHADE, SANJAY PRALHAD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R1-R6, R7a-d, R8a-d, A, M, n, and p are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject. La présente invention concerne des composés de formule (I), leurs formes tautomériques, leurs stéréoisomères, et leurs sels pharmaceutiquement acceptables, (Formule I) (I) dans laquelle R1-R6, R7a-d, R8a-d, A, M, n, et p sont tels que définis dans la description, des compositions pharmaceutiques comprenant un composé, ses tautomères, stéréoisomères, ou sels, et des méthodes de traitement ou de prévention de maladies ou troubles, par exemple, du cancer, sensibles à un traitement ou à une prévention par inhibition de l'enzyme PARP d'un sujet.