ANTIBODIES AND CONJUGATES THAT TARGET MISFOLDED PRION PROTEIN

Human prion protein, PrP, selectively presents the epitope MDEYSNQNN (SEQ ID No. 14) when PrP misfolds. The misfolded form of human PrP is associated with various disease states. The present invention provides an antibody useful to detect and treat such diseases, including cancer such as ovarian can...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	CASHMAN, NEIL R, UGER, MARNI DIANE, CIOLFI, VERONICA, WONG, WAH YAU, CHAI, VIENGTHONG, CHAO, HEMAN LAP-MAN, TIAN, BAOMIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Human prion protein, PrP, selectively presents the epitope MDEYSNQNN (SEQ ID No. 14) when PrP misfolds. The misfolded form of human PrP is associated with various disease states. The present invention provides an antibody useful to detect and treat such diseases, including cancer such as ovarian cancer and lymphomas, and transmissible spongiform encephalopathies such as CJD. Also provided is an immunoconjugate in which the antibody is conjugated with urease as cytotoxin. L'invention concerne une protéine prion humaine, PrP, qui présente sélectivement l'épitope MDEYSNQNN (SEQ ID No. 14) lorsque PrP est mal repliée. La forme mal repliée de la PrP humaine est associée à divers états de maladie. La présente invention concerne un anticorps utile pour détecter et traiter de telles maladies, notamment le cancer, tel que le cancer de l'ovaire et des lymphomes, et des encéphalopathies spongiformes transmissibles, telles que CJD. L'invention concerne également un immuno-conjugué dans lequel l'anticorps est conjugué à l'uréase en tant que cytotoxine.