METHOD FOR THE PREPARATION OF TRIAZOLE COMPOUNDS

METHOD FOR THE PREPARATION OF TRIAZOLE COMPOUNDS

The present invention relates to a method for the preparation of 1-[ 6-(morpholino-4-yl)-pyrimidino-4-yl]-4-(1H-1,2,3-triazolo-1-yl)-1H-pyrazolo-5-ol (I - enol form) or 2-[6-(morpholino-4-yl)-pyrimidino-4-yl]-4-(1H-1,2,3-triazolo-1-yl)-1,2-dihydro-3H-pyrazolo-3-one (I - keto form) and sodium-1-[6-(m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MILITZER, HANSRISTIAN, EGGERT, JOHANNES
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a method for the preparation of 1-[ 6-(morpholino-4-yl)-pyrimidino-4-yl]-4-(1H-1,2,3-triazolo-1-yl)-1H-pyrazolo-5-ol (I - enol form) or 2-[6-(morpholino-4-yl)-pyrimidino-4-yl]-4-(1H-1,2,3-triazolo-1-yl)-1,2-dihydro-3H-pyrazolo-3-one (I - keto form) and sodium-1-[6-(morpholino-4-yl)-pyrimidino-4-yl]-4-(1H-1,2,3-triazolo-1-yl)-1H-pyrazolo-5-olate (II) starting from 1, 2,3-triazole (III), methylbromoacetate (IV-Me-Br) or ethylbromoacetate (IV-Et-Br), 4,6-dichloropyrimidine (VIII), morpholine (IX) and hydrazine (XII). La présente invention concerne un procédé de production de 1-[6-(morpholino-4-yl)pyrimidino-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-ole (forme 1-enol) ou 2-[6-(morpholino-4-yl pyrimidino-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dibydro-3H-pyrazol-3-one (forme I-céto) et sodium-1-[6-(morpbolino-4-yl)pyrimidino-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate (II) à partir de,2,3-triazole (III), bromoacétates d'éthyle (IV-Me-Br) ou bromoacétages d'éthyle (IV-Et-Br), 4,6-dichloropyrimidine (VIII), morpholine (IX) et hydrazine (XII).