GIP-GLP-1 DUAL AGONIST COMPOUNDS AND METHODS

The present invention relates to truncated GIP analogues which comprise one or more substitutions as compared to wiid-type GIP and which may have the property of an altered, preferably increased GLP-1 activity, e.g. as assessed in in vitro efficacy assays. The invention provides GIP-GLP-1 dual agoni...

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Bibliographische Detailangaben
Hauptverfasser:	OSTERLUND, TORBEN, RIBER, DITTE, SHELTON, ANNE PERNILLE TOFTENG, HANSEN, KATE, JESSEN, LENE, JUST, RASMUS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to truncated GIP analogues which comprise one or more substitutions as compared to wiid-type GIP and which may have the property of an altered, preferably increased GLP-1 activity, e.g. as assessed in in vitro efficacy assays. The invention provides GIP-GLP-1 dual agonist compounds and associated methods. La présente invention concerne des analogues du GIP tronqués, qui comprennent une ou plusieurs substitutions par rapport à un GIP de type wiid et qui peuvent avoir la propriété d'une activité GLP-1 altérée, de préférence augmentée, notamment tel qu'évaluée dans des essais d'efficacité in vitro. L'invention concerne également des composés agonistes doubles du GIP-GLP-1 et des méthodes associées.