PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE

Compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3 and A are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease. L'inve...

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Bibliographische Detailangaben
Hauptverfasser:	LYSSIKATOS, JOSEPH, DOTSON, JENNAFER, HEFFRON, TIMOTHY, SWEENEY, ZACHARY KEVIN, CHAN, BRYAN K, BAKER-GLENN, CHARLES, ESTRADA, ANTHONY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3 and A are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease. L'invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci, dans lesquels X, R1, R2, R3 et A sont tel que définis ici. L'invention concerne également des procédés de fabrication des composés et d'utilisation des composés pour le traitement de maladies associées à un récepteur de LRRK2, telles que la maladie de Parkinson.