SALT FORM OF A HUMAN HISTONE METHYLTRANSF ERASE EZH2 INHIBITOR

Abstract Provided herein is N-((4,6-dimethy1-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound. The compound describ...

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Bibliographische Detailangaben
Hauptverfasser:	MATHIEU, STEVEN, SANDERS, KRISTEN, HUANG, KUANUN, CHOI, HYEONG WOOK, KUNTZ, KEVIN WAYNE, CHANDA, ARANI, FANG, FRANK
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Abstract Provided herein is N-((4,6-dimethy1-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound. The compound described above and the Polymorph, or a pharmaceutical composition comprising either of these compounds, may be used to treat a variety of cancers, including non-Hodgkin's lymphoma or breast cancer. Date Recue/Date Received 2020-09-17 La présente invention concerne un bromhydrate de N-((4,6-diméthyl-2-oxo-1,2-dihydropyridin-3-yl)méthyl)-5-(éthyl- (tétrahydro-2H-pyran-4-yl)amino)-4-méthyl-4'-(morpholinométhyl)-[1,1'-biphényl]-3-carboxamide. Une forme polymorphe particulière du présent composé est également décrite dans la description.