APTAMERS TO PDGF AND VEGF AND THEIR USE IN TREATING PDGF AND VEGF MEDIATED CONDITIONS

Aptamers that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the ap...

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Bibliographische Detailangaben
Hauptverfasser:	WAUGH, SHEELA M, JANJIC, NEBOJSA, JARVIS, THALE C, ROHLOFF, JOHN C, GELINAS, AMY D, ZHANG, CHI, DROLET, DANIEL W
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Aptamers that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs. L'invention concerne des aptamères qui se lient à PDGF et des aptamères qui se lient à VEGF. De plus, l'invention concerne des constructions d'aptamères comprenant un aptamère de PDGF et un aptamère de VEGF. L'invention concerne des composés pharmaceutiques comprenant les aptamères et des constructions d'aptamères, ainsi que des méthodes de traitement d'états à l'aide des aptamères et des constructions d'aptamères.