JCV NEUTRALIZING ANTIBODIES

In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1 ). In some embodiments, the antibody s...

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Hauptverfasser:	ARNDT, JOSEPH, RUSHE, MIA, SIMON, KENNETH, CARAVELLA, JUSTIN, DAY, ERIC, CAMERON, THOMAS, WANG, DEPING
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1 ). In some embodiments, the antibody suppresses infectivity of the JC-vims. In some embodiments, the antibody binds the sialic acid binding pocket of JCV-VP1. Dans un aspect, l'invention concerne des anticorps neutralisants contre JCV et des procédés pour le traitement de PML. Dans certains modes de réalisation, aspects de l'invention concernent un virus JC-isolé anticorps monoclonaux neutralisants contre JCV protéine de capside VP1 (JCV-VP1) Dans certains modes de réalisation, l'anticorps supprime l'infectivité des virus JC-. Dans certains modes de réalisation, l'anticorps se lie à la poche de liaison de JCV - VP1 à acide sialique.