CRYSTALLINE FORM OF A SUCCINATE SALT

This invention relates to a new crystalline form of the succinate salt of the epithelial sodium channel (ENaC) blocker 3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8- triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester, pharmaceut...

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Hauptverfasser:	TUFILLI, NICOLA, HOWSHAM, CATHERINE, LINDENBERG, CHRISTIAN, PERLBERG, ANETT
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to a new crystalline form of the succinate salt of the epithelial sodium channel (ENaC) blocker 3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8- triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester, pharmaceutical compositions comprising said crystalline form, uses of said crystalline form and pharmaceutical compositions, and methods for preparing said crystalline form. La présente invention concerne une nouvelle forme cristalline du sel de succinate du bloqueur du canal sodique épithélial (ENaC), ester dipropylcarbamoylméthylique de l'acide 3-(3-{2-[(E)-3,5-diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]décane-8-carbonyle}-benzènesulfonylamino)-propionique, des compositions pharmaceutiques comprenant ladite forme cristalline, des utilisations de ladite forme cristalline et des compositions pharmaceutiques, ainsi que des procédés de préparation de ladite forme cristalline.