PHARMACEUTICAL COMPOSITIONS COMPRISING A SOLID DISPERSION OF N-[2,4-BIS(1,1-DIMETHYLETHYL0-5-HYDROXYPHENYL-1]-1,4-DIHYDRO-4-OXOQUINOLONE-3-CARBOXAMIDE FOR TREATING CYSTIC FIBROSIS

The present invention relates to pharmaceutical compositions containing a solid dispersion of N- [2,4-B is( 1, 1 -dimethy lethyl)-5 -hydroxypheny 1] - 1,4-dihydro-4-oxoquinoline-3 - carboxamide including formulations of the solid dispersions into powders, granules and mini- tablets, methods for manu...

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Bibliographische Detailangaben
Hauptverfasser:	GU, CHONG-HUI, DAS, LAURA, HURTER, PATRICIA NELL, KNEZICAGUTIN, CAESAR, JOHN P., JR, FAWAZ, MAJED, ISRANI, MEGHNA JAI, JOHNSTON, MEGHAN M, KUZMISSION, ANDREW G, JAMZAD, SHAHLA, WANG, HONGREN, DOKOU, ELENI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical compositions containing a solid dispersion of N- [2,4-B is( 1, 1 -dimethy lethyl)-5 -hydroxypheny 1] - 1,4-dihydro-4-oxoquinoline-3 - carboxamide including formulations of the solid dispersions into powders, granules and mini- tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition. La présente invention concerne des compositions pharmaceutiques contenant une dispersion solide de N-[2,4-bis(1,1-diméthyléthyl)-5-hydroxyphényl]-1,4-dihydro-4-oxoquinoléine-3-carboxamide comprenant des formulations des dispersions solides en poudres, granulés et mini-comprimés, des procédés de fabrication et de traitement des poudres, granulés et mini-comprimés, et des procédés de traitement de la fibrose kystique utilisant la composition pharmaceutique.