SUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND USES THEREOF

SUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND USES THEREOF

This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of s...

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Bibliographische Detailangaben
Hauptverfasser: HUBSCH, WALTER, HEROULT, MELANIE, BOMER, ULF, LINDNER, NIELS, BROHM, DIRK, COLLIN, MARIE-PIERRE, LOBELL, MARIO, VOEHRINGER, VERENA, LUSTIG, KLEMENS, SCHIROK, HARTMUT, GRUNEWALD, SYLVIA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases. Cette invention se rapporte à de nouveaux dérivés 5-(1-benzothiophén-2-yl)pyrrolo [2,1-f] [1,2,4]triazin-4-amine, dérivés possédant des activités inhibitrices de la protéine tyrosine kinase, à des procédés pour la préparation de ces composés, à des compositions pharmaceutiques contenant de tels composés et à l'utilisation de tels composés ou compositions pour le traitement de troubles prolifératifs, particulièrement le cancer et les maladies tumorales.