PROCESSES USING VLPS WITH CAPSIDS RESISTANT TO HYDROLASES

Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNA's and shRNA's, and small peptides....

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Bibliographische Detailangaben
Hauptverfasser:	DELANEY, KIMBERLY, SUMMERS, NEENA, ARHANCET, JUAN P, HALL, KATHLEEN B, ARHANCET, JUAN PEDRO HUMBERTO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNA's and shRNA's, and small peptides. La présente invention concerne de nouveaux procédés et compositions qui utilisent des protéines de capside viral résistantes aux hydrolases pour préparer des particules de type viral pour encapsuler et ensuite isoler et purifier des molécules d'intérêt de charge cibles comprenant des acides nucléiques tels que des ARNsi et des ARNsh et des petits peptides.