4,4-DISUBSTITUTED-1,4-DIHYDROPYRIMIDINES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1-R5, B and Z have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containi...

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Hauptverfasser:	RABOISSON, PIERRE JEAN-MARIE BERNARD, VANDYCK, KOEN, HACHE, GEERWIN YVONNE PAUL, ROMBOUTS, GEERT, VERSCHUEREN, WIM GASTON
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1-R5, B and Z have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy. L'invention concerne des inhibiteurs de la réplication du VHB de formule (I), y compris les formes isomères stéréochimiques et les sels, hydrates et solvates associés, R1 à R5, B et Z ayant la signification telle que définie dans le présent document. La présente invention concerne également des procédés de préparation desdits composés, des compositions pharmaceutiques les contenant et leur utilisation, seuls ou en combinaison avec d'autres inhibiteurs du VHB, pour le traitement du VHB.