INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATION

The inventive compounds are small molecule therapeutics that are potent inhibitors of Arginase I and II activity. The invention also provides pharmaceutical compositions of the inventive compounds and methods for using the inventive compounds for treating or preventing a disease or a condition assoc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	WHITEHOUSE, DARREN, VAN ZANDT, MICHAEL, GOLEBIOWSKI, ADAM, RYDER, TODD, BECKETT, RAYMOND PAUL, JI, MIN KOO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The inventive compounds are small molecule therapeutics that are potent inhibitors of Arginase I and II activity. The invention also provides pharmaceutical compositions of the inventive compounds and methods for using the inventive compounds for treating or preventing a disease or a condition associated with arginase activity. Les composés selon l'invention sont des agents thérapeutiques à petite molécule qui sont de puissants inhibiteurs de l'activité de l'arginase I et II. L'invention concerne également des compositions pharmaceutiques contenant ces composés, ainsi que des procédés d'utilisation des composés selon l'invention pour le traitement ou la prévention d'une maladie ou d'une affection associée à l'activité de l'arginase.