PEPTIDES AND METHODS FOR THE DETECTION OF LYME DISEASE ANTIBODIES

PEPTIDES AND METHODS FOR THE DETECTION OF LYME DISEASE ANTIBODIES

Compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens are disclosed. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VIsE protein. Also provided are devices, methods, and kits comp...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BLEILE, DENNIS M, MEHRA, RAJESH K, ARON, KENNETH P, WALKER, JEREMY, CUESICO, CRISTINA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
COMBINATORIAL CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:Compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens are disclosed. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VIsE protein. Also provided are devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease. La présente invention concerne des compositions (par exemple, des compositions de peptides) utiles pour détecter des anticorps se liant à des antigènes de Borrelia. Les compositions de peptides comprennent des séquences polypeptidiques comprenant des variants dans le domaine IR6 de la protéine VIsE de Borrelia. L'invention concerne également des dispositifs, des procédés et des kits comprenant ces compositions de peptides et utiles pour détecter des anticorps se liant à des antigènes de Borrelia et diagnostiquer la maladie de Lyme.