5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3,4-B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS

5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3,4-B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS

The present application relates to a series of substituted pyrazolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. (See Formula I) Wherein R, R1, R2, R a, R aa, R b and n are as defined herein. The present invention furth...

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Bibliographische Detailangaben
Hauptverfasser: BORUAH, ANIMA, ALIKUNJU, SHANAVAS
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present application relates to a series of substituted pyrazolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. (See Formula I) Wherein R, R1, R2, R a, R aa, R b and n are as defined herein. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I). The compounds of this application are useful as CETP inhibitors for increasing HDL cholesterol and decreasing LDL cholesterol in a patient.