DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS

DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS

The present invention provides novel 6-substituted [1,2,4]triazolo[4,3-b]pyridazines that are agonists of Rev-Erb. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the activation of Rev-Erb has therapeutic effects, for instance...

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Bibliographische Detailangaben
Hauptverfasser: DUBERNET, MATHIEU, GOUY, MARIE-HELENE, BOUROTTE, MARYLINE, DELHOMEL, JEAN-FRANCOIS
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides novel 6-substituted [1,2,4]triazolo[4,3-b]pyridazines that are agonists of Rev-Erb. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the activation of Rev-Erb has therapeutic effects, for instance in inflammatory and circadian rhythm-related disorders or cardiometabolic diseases. La présente invention concerne de nouvelles [1,2,4]triazolo[4,3-b]pyridazines 6-substituées qui sont des agonistes de Rev-Erb. Ces composés, et des compositions pharmaceutiques comprenant ceux-ci, sont des moyens adaptés pour traiter une maladie quelconque dans laquelle l'activation de Rev-Erb a des effets thérapeutiques, par exemple dans des troubles inflammatoires et associés au rythme circadien ou des maladies cardiométaboliques.