TREATMENT OF COAGULATION DISEASE BY ADMINISTRATION OF RECOMBINANT VWF

The present invention provides methods of treating coagulation disease, including hemophilia and von Willebrand disease by administering recombinant von Willebrand Factor alone or in combination with Factor VIII, wherein the rVWF is a high molecular weight VWF multimer composition comprising at leas...

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Bibliographische Detailangaben
Hauptverfasser: EWENSTEIN, BRUCE, SUITER, TOBIAS M, TURECEK, PETER, SCHEIFLINGER, FRIEDRICH, WONG, WING YEN
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The present invention provides methods of treating coagulation disease, including hemophilia and von Willebrand disease by administering recombinant von Willebrand Factor alone or in combination with Factor VIII, wherein the rVWF is a high molecular weight VWF multimer composition comprising at least 20%, or at least 40%, VWF decamers or higher order multimers. La présente invention concerne des procédés de traitement d'une maladie de la coagulation, incluant l'hémophilie et la maladie de von Willebrand par l'administration d'un facteur de von Willebrand recombinant seul ou en combinaison avec le facteur VIII.