4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE

4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE

Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone. L'invention porte sur des composés qui peuvent être utilisés pour inhiber la pectine acétylestérase d...

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Hauptverfasser: MABON, ROSS, CARSON, KENNETH GORDON, XU, XIAOLIAN, TARVER, JAMES, BARBOSA, JOSEPH, HEALY, JASON PATRICK, GARDYAN, MICHAEL WALTER, HAN, QIANG, TUNOORI, ASHOK, PABBA, PRAVEEN, TERRANOVA, KRISTEN M
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone. L'invention porte sur des composés qui peuvent être utilisés pour inhiber la pectine acétylestérase de notum, ainsi que sur des compositions les comprenant et sur leurs procédés d'utilisation pour traiter des troubles et des maladies touchant les os.