GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

Abstract The invention relates to inhibitors of glucosylceramide synthase (GCS) of Formula I useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer. 87FA ).tx1 R 2 7-1- X X3 A2 n...

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Hauptverfasser:	SKERLJ, RENATO, MARSHALL, JOHN, BOURQUE, ELYSE, XIANG, YIBIN, HIRTH, BRADFORD, CHENG, SENG, JANCISICS, KATHERINE, METZ, MARKUS, CELATKA, CASSANDRA, SCHEULE, RONALD, ZHAO, ZHONG, GOOD, ANDREW, CABRERA-SALAZAR, MARIO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Abstract The invention relates to inhibitors of glucosylceramide synthase (GCS) of Formula I useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer. 87FA ).tx1 R 2 7-1- X X3 A2 n X - - P CA 2830540 2018-09-25 L'invention concerne des inhibiteurs de la glucosylcéramide synthase (GCS) utilisés pour traiter des maladies métaboliques, telles que des maladies du stockage lysosomal, seuls ou en association avec une enzymothérapie substitutive, et pour traiter le cancer.