METHODS AND COMPOSITIONS FOR PREDICTING RESPONSE TO ERIBULIN

The invention provides methods for predicting the efficacy of eribulin, an analog thereof, or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate), in the treatment of a subject suffering from breast cancer by determining the level of particular biomarkers in a sample derived from th...

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Bibliographische Detailangaben
Hauptverfasser:	AGOULNIK, SERGEI I, BYRNE, MICHAEL CHAPMAN, LITTLEFIELD, BRUCE A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides methods for predicting the efficacy of eribulin, an analog thereof, or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate), in the treatment of a subject suffering from breast cancer by determining the level of particular biomarkers in a sample derived from the subject. La présente invention concerne des procédés destinés à prédire l'efficacité de l'éribuline, de l'un de ses analogues, ou de l'un de ses sels pharmaceutiquement admis (par exemple, le mésylate d'éribuline) dans le traitement d'un sujet soufrant du cancer du sein, ces procédés consistant à déterminer le niveau de biomarqueurs particuliers dans un échantillon prélevé chez le sujet.