REGIOSELECTIVE ACYLATION OF RAPAMYCIN AT THE C-42 POSITION

REGIOSELECTIVE ACYLATION OF RAPAMYCIN AT THE C-42 POSITION

The invention refers to the selective acylation of Rapamycin at the 42-position (I) with an acylating agent of the formula (II) wherein R4 and R5 are the same or different, individually the rest of an acetal, especially tetrahydropyran, or of a carbonate or the rest of a silyl ether or taken togethe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FELZMANN, WOLFGANG, SCHONE, NIKLAS
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention refers to the selective acylation of Rapamycin at the 42-position (I) with an acylating agent of the formula (II) wherein R4 and R5 are the same or different, individually the rest of an acetal, especially tetrahydropyran, or of a carbonate or the rest of a silyl ether or taken together are the rest of a boronate, an acetal or ketal.