ALKYNE SUBSTITUTED QUINAZOLINE COMPOUNDS AND METHODS OF USE

ALKYNE SUBSTITUTED QUINAZOLINE COMPOUNDS AND METHODS OF USE

The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (l), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MAUNG, JACK, SHEN, WANG, ZHANG, AIMIN, ZHENG, XIAOLING
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (l), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer). Abrégé : L'invention concerne des composés quinazoline substitués par un alcyne, tels que des composés de la formule (I) qui sont des inhibiteurs irréversibles de la kinase ErbB. Les composés sont utiles dans le traitement de maladies et de troubles où l'activité kinase ErbB est impliquée, comme dans le cadre d'un trouble d'hyperprolifération (par exemple, le cancer).