TUMOR NECROSIS FACTOR-A HUMANIZED ANTIBODY

The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SUN, CECILY ROU-YUN, LI, QIANG, TAO, DESHENG, HU, ZHENXIANG, ZHU, BAOGUO, SUN, BILL NAIAU, SUN, LEE-HWEI KING, LIOU, RUEY SHYAN, PENG, YUCAI, ZHANG, JINGWEI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric antibody. Therefore, safety of the antibody in clinical applications has been improved. La présente invention concerne un anticorps monoclonal humanisé anti-facteur de nécrose tumoral a et une séquence d'acide nucléique codée de celui-ci, un vecteur comprenant la séquence d'acide nucléique et une cellule hôte de celle-ci. La présente invention concerne en outre une composition pharmaceutique comprenant l'anticorps humanisé et une utilisation de celle-ci dans la préparation d'un médicament. Le médicament est applicable dans le diagnostic et le traitement de maladies associées à hTNFa.