PYRIMIDINE GYRASE AND TOPOISOMERASE IV INHIBITORS

The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either...

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Bibliographische Detailangaben
Hauptverfasser:	LE TIRAN, ARNAUD, PEROLA, EMANUELE, CHARIFSON, PAUL, BENNANI, YOUSSEF LAAFIRET, O'DOWD, HARDWIN, GRILLOT, ANNE-LAURE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti¬ bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity. L'invention concerne un composé de formule (I) : ou un sel de celui-ci pharmaceutiquement acceptable ; X et R sont tels que définis dans le descriptif. Les composés de formule (I) sont utilisés comme inhibiteurs de gyrase et/ou topoïsomérase IV pour traiter des infections bactériennes. Les composés de formule (I) possèdent un large spectre d'activité antibactérienne et des propriétés toxicologiques avantageuses ; ils sont également des promédicaments de composés ayant ladite activité.