NEW AMPHOTERICIN ANALOGOUS COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

NEW AMPHOTERICIN ANALOGOUS COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to polyene macrolide derivatives according to the formula (I): wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocyclo...

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Bibliographische Detailangaben
Hauptverfasser: LEON BUITIMEA, ANGEL, FLORES ROMERO, JOSE DAVID, JIMENEZ MONTEJO, FABIOLA ELOISA, RODRIGUEZ FRAGOSO, MARIA DE LOURDES, OCAMPO MARTINEZ, LILIA, SANTIAGO ANGELINO, TANIA MINERVA, VARGAS GONZALEZ, MARIA CRISTINA, CARRILLO TRIPP, MAURICIO, REYES ESPARZA, JORGE ALBERTO, ANTILLON DIAZ, ARMANDO, ORTEGA BLAKE, IVAN, FERNANDEZ ZERTUCHE, MARIO, MORALES NAVA, ROSMARBEL
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:The present invention relates to polyene macrolide derivatives according to the formula (I): wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.