CRYSTALLINE FORMS OF 1-[(3R)-6,8-DIFLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-3-YL]-1,3-DIHYDRO-5- [2-[(PHENYLMETHYL)AMINO]ETHYL] -2H-IMIDAZOLE-2-THIONE AND PROCESSES FOR THEIR PREPARATIONS

CRYSTALLINE FORMS OF 1-[(3R)-6,8-DIFLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-3-YL]-1,3-DIHYDRO-5- [2-[(PHENYLMETHYL)AMINO]ETHYL] -2H-IMIDAZOLE-2-THIONE AND PROCESSES FOR THEIR PREPARATIONS

The present invention relates to crystalline Form A of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione and crystalline Form B of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethy...

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Hauptverfasser: LEARMONTH, DAVID ALEXANDER, ALBERT, EKATERINA, BROADBELT, BRIAN, BELIAEV, ALEXANDER, ANDRES, PATRICIA
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator LEARMONTH, DAVID ALEXANDER
ALBERT, EKATERINA
BROADBELT, BRIAN
BELIAEV, ALEXANDER
ANDRES, PATRICIA
description The present invention relates to crystalline Form A of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione and crystalline Form B of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione, processes for preparing the forms and their uses in medicine. The present invention also relates to the amorphous form of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione processes for preparing it and its uses in medicine. La présente invention concerne une forme cristalline A de 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione et une forme cristalline B de 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione, des procédés pour la préparation de ces formes et leurs utilisations dans des médicaments. La présente invention concerne également la forme amorphe de la 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione, des procédés pour sa préparation et ses utilisations dans des médicaments.
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The present invention also relates to the amorphous form of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione processes for preparing it and its uses in medicine. La présente invention concerne une forme cristalline A de 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione et une forme cristalline B de 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione, des procédés pour la préparation de ces formes et leurs utilisations dans des médicaments. La présente invention concerne également la forme amorphe de la 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione, des procédés pour sa préparation et ses utilisations dans des médicaments.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20200714&amp;DB=EPODOC&amp;CC=CA&amp;NR=2822681C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20200714&amp;DB=EPODOC&amp;CC=CA&amp;NR=2822681C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEARMONTH, DAVID ALEXANDER</creatorcontrib><creatorcontrib>ALBERT, EKATERINA</creatorcontrib><creatorcontrib>BROADBELT, BRIAN</creatorcontrib><creatorcontrib>BELIAEV, ALEXANDER</creatorcontrib><creatorcontrib>ANDRES, PATRICIA</creatorcontrib><title>CRYSTALLINE FORMS OF 1-[(3R)-6,8-DIFLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-3-YL]-1,3-DIHYDRO-5- [2-[(PHENYLMETHYL)AMINO]ETHYL] -2H-IMIDAZOLE-2-THIONE AND PROCESSES FOR THEIR PREPARATIONS</title><description>The present invention relates to crystalline Form A of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione and crystalline Form B of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione, processes for preparing the forms and their uses in medicine. The present invention also relates to the amorphous form of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione processes for preparing it and its uses in medicine. La présente invention concerne une forme cristalline A de 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione et une forme cristalline B de 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione, des procédés pour la préparation de ces formes et leurs utilisations dans des médicaments. 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The present invention also relates to the amorphous form of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione processes for preparing it and its uses in medicine. La présente invention concerne une forme cristalline A de 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione et une forme cristalline B de 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione, des procédés pour la préparation de ces formes et leurs utilisations dans des médicaments. La présente invention concerne également la forme amorphe de la 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione, des procédés pour sa préparation et ses utilisations dans des médicaments.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title CRYSTALLINE FORMS OF 1-[(3R)-6,8-DIFLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-3-YL]-1,3-DIHYDRO-5- [2-[(PHENYLMETHYL)AMINO]ETHYL] -2H-IMIDAZOLE-2-THIONE AND PROCESSES FOR THEIR PREPARATIONS
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