CRYSTALLINE FORMS OF 1-[(3R)-6,8-DIFLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-3-YL]-1,3-DIHYDRO-5- [2-[(PHENYLMETHYL)AMINO]ETHYL] -2H-IMIDAZOLE-2-THIONE AND PROCESSES FOR THEIR PREPARATIONS

CRYSTALLINE FORMS OF 1-[(3R)-6,8-DIFLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-3-YL]-1,3-DIHYDRO-5- [2-[(PHENYLMETHYL)AMINO]ETHYL] -2H-IMIDAZOLE-2-THIONE AND PROCESSES FOR THEIR PREPARATIONS

The present invention relates to crystalline Form A of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione and crystalline Form B of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethy...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LEARMONTH, DAVID ALEXANDER, ALBERT, EKATERINA, BROADBELT, BRIAN, BELIAEV, ALEXANDER, ANDRES, PATRICIA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention relates to crystalline Form A of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione and crystalline Form B of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione, processes for preparing the forms and their uses in medicine. The present invention also relates to the amorphous form of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione processes for preparing it and its uses in medicine. La présente invention concerne une forme cristalline A de 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione et une forme cristalline B de 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione, des procédés pour la préparation de ces formes et leurs utilisations dans des médicaments. La présente invention concerne également la forme amorphe de la 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyrann-3-yl]-1,3-dihydro-5-[2-[(phénylméthyl)amino]éthyl]-2H-imidazole-2-thione, des procédés pour sa préparation et ses utilisations dans des médicaments.