ANTI-C5/C5A/C5ADESR ANTIBODIES AND FRAGMENTS

Provided are compositions, methods of manufacture and methods of use pertaining to anti-C5/C5a/C5adesR antibodies and antigen binding fragments. Specifically, the disclosure provides an isolated antibody or antigen-binding fragment thereof which immunospecifically binds to one or more of a C5 polype...

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Bibliographische Detailangaben
Hauptverfasser:	COLLEY, CAROLINE, DOBSON, CLAIRE, BRENNAN, JOANNE, FUNG, SEK
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are compositions, methods of manufacture and methods of use pertaining to anti-C5/C5a/C5adesR antibodies and antigen binding fragments. Specifically, the disclosure provides an isolated antibody or antigen-binding fragment thereof which immunospecifically binds to one or more of a C5 polypeptide, a C5a polypeptide and a C5adesR polypeptide, and has one or more of the characteristics including affinity (Kd) for the antigen(s) that binds, and activity in inhibiting one or more functions mediated by associated antigens. Further disclosed are sequences for each antibody.