POLYMORPHIC AND AMORPHOUS SALT FORMS OF SQUALAMINE DILACTATE

POLYMORPHIC AND AMORPHOUS SALT FORMS OF SQUALAMINE DILACTATE

The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GILBERT, CHARLES, CHELLQUIST, ERIC, DOUBLEDAY, MARY, ZHANG, XUEHAI, LEVITT, ROY C, MCLANE, MICHAEL, ARMBRUSTER, KYLE
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Beschreibung
Zusammenfassung:The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation. L'invention porte sur la sélection de sels de squalamine, des méthodes de synthèse associées, leur utilisation thérapeutique et leurs avantages relativement à la fabrication, la stabilité du produit et la toxicité du produit. Plus spécifiquement, cette demande porte sur diverses formes de sel de dilactate de squalamine et leur utilité dans l'inhibition de la néovascularisation et la prolifération de cellules endothéliales.