DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME

Disclosed herein are compounds having formula (II), formula (IIa) or formula (III) and their salts: or Also disclosed are uses of these compounds for inhibiting cell proliferation for example in cancer; for inhibiting a pathogenic infection; for treating a neurodegenerative disease; or for treating...

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Bibliographische Detailangaben
Hauptverfasser:	SHOWALTER, H.D. HOLLIS, TALPAZ, MOSHE, O'RIORDAN, MARY XUAN DZIEM, WOBUS, CHRISTIANE, PERRY, JEFFREY WILLIAM, JIN, YAFEI, DONATO, NICHOLAS J, SORENSON, RODERICK JOSEPH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are compounds having formula (II), formula (IIa) or formula (III) and their salts: or Also disclosed are uses of these compounds for inhibiting cell proliferation for example in cancer; for inhibiting a pathogenic infection; for treating a neurodegenerative disease; or for treating one or more symptoms associated with a genetic disease. La présente invention concerne des procédés d'inhibition d'une déubiquitinase (DUB), des méthodes de traitement d'infections pathogènes (par exemple virales, bactériennes et/ou parasitaires), des procédés d'inhibition de la prolifération cellulaire, des méthodes de traitement d'une maladie neurodégénérative, des méthodes de traitement d'un ou plusieurs symptômes d'une maladie neurodégénérative ou d'un trouble génétique, et des composés.