QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS

QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS

A series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological,...

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Bibliographische Detailangaben
Hauptverfasser: LANGHAM, BARRY JOHN, NEUSS, JUDI CHARLOTTE, QUINCEY, JOANNA RACHEL, FORD, DANIEL JAMES, BROWN, JULIEN ALISTAIR, ALI, MEZHER HUSSEIN, PARTON, ANDREW HARRY, FRANKLIN, RICHARD JEREMY, BROOKINGS, DANIEL CHRISTOPHER
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. Série de dérivés de quinoline et de quinoxaline comprenant une chaîne latérale éthyle fluoré, lesdits dérivés étant des inhibiteurs sélectifs des enzymes kinases P13 qui sont, par conséquent, utiles en médecine, par exemple, pour traiter des affections inflammatoires, auto-immunes, cardiovasculaires, neurodégénératives, métaboliques, oncologiques, nociceptives ou ophtalmiques.