2-ANILINOBENZIMIDAZOLE-6-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS

This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M,...

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Bibliographische Detailangaben
Hauptverfasser:	ROENN, ROBERT, KUELZER, RAIMUND, PRIEPKE, HENNING, PELCMAN, BENJAMIN, DOODS, HENRI, STENKAMP, DIRK, PFAU, ROLAND
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description. La présente invention concerne des composés de formule (I) et leur utilisation en tant qu'inhibiteurs de la prostaglandine E2 synthase-1 microsomale (mPGES-1), des compositions pharmaceutiques les contenant, et leur utilisation en tant que médicaments pour le traitement et/ou la prévention de maladies inflammatoires et de conditions associées. Dans la formule (I), A, M, W, R1, R2, R6, R7, R8 sont tels que définis dans la description.