PROCESS FOR THE SYNTHESIS AND PURIFICATION OF OXYCODONE

PROCESS FOR THE SYNTHESIS AND PURIFICATION OF OXYCODONE

A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8, 14-dihydroxy-7,8-dihydrocodeinone, is reduc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DUNG, JEN-SEN, KESKENY, ERNO M, MENCEL, JAMES J
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8, 14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14- hydroxycodeinone and can be readily separated from oxycodone.