METHOD FOR CANCER THERAPY

This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	OLIVA ARGUELLES, BRIZAIDA MAYLIN, MUSACCHIO LASA, ALEXIS, FERNANDEZ MASSO, JULIO RAUL, GUERRA VALLESPI, MARIBEL, GIL VALDES, JEOVANIS, REYES ACOSTA, OSVALDO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide. La présente invention concerne une méthode pour le traitement du cancer par l'augmentation de la localisation nucléaire de la protéine COMMD1, laquelle est associée à la diminution ou blocage de la prolifération de la cellule du cancer. L'invention concerne, en outre, l'utilisation d'agents qui augmentent la localisation nucléaire de la protéine COMMD1 dans la fabrication d'un médicament pour le traitement du cancer. Lesdits agents peuvent être des peptides ou des protéines, entre autres composés. L'invention concerne également l'optimisation d'un peptide, provenant de la séquence HARIKPTFRRLKWKKYKGKFW, pour augmenter la localisation nucléaire de la protéine COMMD1 et ainsi augmenter l'effet antitumoral dudit peptide.