2,3 DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO [3.5] NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR

The present invention provides a compound of Formula (I) or a pharmaceutically salt thereof wherein R1, R2, Ra, L, Z, Z1 and Z2 are as defined herein, that act as Ghrelin antagonists or inverse agonists; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions...

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Bibliographische Detailangaben
Hauptverfasser:	LONDREGAN, ALLYN TIMOTHY, CAMERON, KIMBERLY O'KEEFE, MCCLURE, KIM FRANCIS, BHATTACHARYA, SAMIT KUMAR, SIMILA, SUVI TUULA MARJUKKA, KUNG, DANIEL WEI-SHUNG, FERNANDO, DILINIE PRASADHINI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a compound of Formula (I) or a pharmaceutically salt thereof wherein R1, R2, Ra, L, Z, Z1 and Z2 are as defined herein, that act as Ghrelin antagonists or inverse agonists; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by the antagonism of the Ghrelin receptor. Cette invention concerne un composé de Formule (I) ou un sel pharmaceutiquement acceptable de celui-ci qui agit comme un antagoniste ou un agoniste inverse de la ghréline ; des compositions pharmaceutiques le contenant ; et des méthodes pour traiter des maladies, des troubles, ou des affections médiés par l'antagonisme du récepteur de la ghréline. Dans la Formule (I), R1, R2, Ra, L, Z, Z1 et Z2 sont tels que définis dans la description.