MODULATION OF ANGIOGENESIS

The invention provides methods for treating pathological conditions that can be improved by providing angiogenesis. The invention is generally directed to provide angiogenesis by administering cells that express and/or secrete one or more pro-angiogenic factors. The invention is also directed to dru...

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Bibliographische Detailangaben
Hauptverfasser:	TING, ANTHONY E, LEHMAN, NICHOLAS A, WODA, JULIANA MEGAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides methods for treating pathological conditions that can be improved by providing angiogenesis. The invention is generally directed to provide angiogenesis by administering cells that express and/or secrete one or more pro-angiogenic factors. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to express and/or secrete one or more pro-angiogenic factors. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired levels of expression and/or secretion of one or more pro-angiogenic factors. L'invention concerne des procédés de traitement d'états pathologiques qui peuvent être améliorés en permettant l'angiogenèse. L'invention est dirigée d'une manière générale vers l'activation de l'angiogenèse par l'administration de cellules qui expriment et /ou sécrètent un ou plusieurs facteurs pro-angiogénique(s). L'invention concerne également des procédés de découverte de médicaments pour cribler des agents qui modulent la capacité des cellules à exprimer et/ou à sécréter un ou plusieurs facteur(s) pro-angiogénique(s). L'invention est également dirigée vers des banques de cellules qui peuvent être employées pour fournir des cellules pour l'administration à un sujet, les banques comprenant des cellules ayant les niveaux souhaités d'expression et/ou de sécrétion d'un ou plusieurs facteur(s) pro-angiogénique(s).