POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS

POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS

The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CONNOR, ERIC, COPE, MICHAEL JAMES, SHAO, JUN, LEE, ANGELA, GOKA, ELIZABETH, ZHANG, XINNAN, ZHANG, HONGMIN, LEES, INEZ, MADSEN, DEIDRE, BIYANI, KALPESH, HECKER, SCOTT
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
COMPOSITIONS BASED THEREON
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like. La présente invention concerne des polymères aminés réticulés pouvant se lier et éliminer efficacement les sels biliaires du tractus gastro-intestinal. Ces polymères se liant à l'acide biliaire ou leurs compositions pharmaceutiques peuvent être administrés à des sujets dans le traitement d'états pathologiques divers, y compris l'hypercholestérolémie, le diabète, le prurit, le syndrome du colon irritable avec diarrhées (SCI-D), la malabsorption de l'acide biliaire, etc.