GASTRORETENTIVE SOLID ORAL DOSAGE FORMS WITH SWELLABLE HYDROPHILIC POLYMER

GASTRORETENTIVE SOLID ORAL DOSAGE FORMS WITH SWELLABLE HYDROPHILIC POLYMER

The disclosure provides multiparticulate systems that give release of active agents with a narrow window of absorption such that there is bioavailability to a patient. The disclosure provides a composition comprising microparticulates comprising a swellable hydrophilic polymer and an active agent, w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CHIN, SHOOK-FONG, MASAND, NATASHA G, ALANI, LAMAN LYNN, DING, GUANGBIN, KOU, JIM H
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The disclosure provides multiparticulate systems that give release of active agents with a narrow window of absorption such that there is bioavailability to a patient. The disclosure provides a composition comprising microparticulates comprising a swellable hydrophilic polymer and an active agent, wherein the swellable hydrophilic polymer is substantially non-crosslinked intramolecularly; and the size of the microparticulates is about 500 µm or less.