PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS

The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase associated conditions including inflammation,...

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Bibliographische Detailangaben
Hauptverfasser:	REGAN, COLLIN F, RYCKMAN, DAVID M, HADDACH, MUSTAPHA, RAVULA, SUCHITRA, PIERRE, FABRICE, TRAN, JOE A, RAFFAELE, NICHOLAS B
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase associated conditions including inflammation, pain, and certain immunological disorders, and have the following general formula (I).. La présente invention a pour objet des composés qui inhibent l'activité de protéine kinase CK2 (activité CK2), et des compositions contenant de tels composés. Ces composés et ces compositions sont utiles pour le traitement de troubles prolifératifs tels que le cancer, ainsi que d'autres états pathologiques associés à la kinase, y compris une inflammation, une douleur, et certains troubles immunologiques, et ont la formule générale suivante (I).