MICROSPHERES OF HYDROLYSED STARCH WITH ENDOGENOUS, CHARGED LIGANDS

The present invention relates to biodegradable microspheres having a diameter of 10-2000 µm comprising cross-linked hydrolysed starch onto which at least one type of ligand has been coupled via a carboxylic ester bond. The ligand shall be an endogenous, charged molecule with a molecular mass of less...

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Bibliographische Detailangaben
Hauptverfasser:	MALMSJOE, MALIN, FYHR, PETER, THORDARSON, EDDIE, APELL, STEN PETER
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF DISINFECTION, STERILISATION, OR DEODORISATION OF AIR GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP WORKING-UP
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Beschreibung
Zusammenfassung:	The present invention relates to biodegradable microspheres having a diameter of 10-2000 µm comprising cross-linked hydrolysed starch onto which at least one type of ligand has been coupled via a carboxylic ester bond. The ligand shall be an endogenous, charged molecule with a molecular mass of less than 1000 Da comprising at least one additional carboxylic acid function in addition to the one utilised for coupling the ligand to the micro¬ sphere and/or at least one amine function. On average 0.05-1.5 ligands are coupled to each glucose moiety in the hydrolysed starch. L'invention porte sur des microsphères biodégradables d'un diamètre de 10-2000 µm comprenant de l'amidon réticulé hydrolysé auquel a été couplé au moins un type de ligand par l'intermédiaire d'une liaison ester carboxylique. Le ligand sera une molécule endogène chargée, d'une masse de moins de 1000 Da, comportant au moins une fonction additionnelle d'acide carboxylique s'ajoutant à celle utilisée pour coupler le ligand à la microsphère, et/ou au moins une fonction amine. En moyenne de 0,05 à 1,5 ligands sont couplés à chaque fragment de glucose de l'amidon hydrolysé.