5-IMINO-1,2,4-THIADIAZOLES DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention is based on the use of a broad family of 5-imino-1,2,4-thiadiazoles as potential new drugs for the treatment of diseases in which PDE7 inhibition is important, specially inflammatory diseases, autoimmune and neurodegenerative disorders. On the other hand, compounds of the 5-imi...

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Bibliographische Detailangaben
Hauptverfasser:	PEREZ CASTILLO, ANA MARIA, PEREZ FERNANDEZ, DANIEL, LOZA GARCIA, MARIA ISABEL, GIL AYUSO-GONTAN, CARMEN, PALOMO RUIZ, VALLE, MARTINEZ GIL, ANA, PEREZ MARTIN, CONCEPCION, CADAVID TORRES, MARIA ISABEL, BREA FLORIANI, JOSE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is based on the use of a broad family of 5-imino-1,2,4-thiadiazoles as potential new drugs for the treatment of diseases in which PDE7 inhibition is important, specially inflammatory diseases, autoimmune and neurodegenerative disorders. On the other hand, compounds of the 5-imino-1,2,4-thiadiazole family are here described, as well as their synthetic procedures, and they may have great application as drug or drug candidates. Therefore, a first aspect of the present invention is related to a compound of formula (I): La présente invention concerne l'utilisation d'une grande famille de substitués 1,2,4-tiadiazoles-5-imino en tant que nouveaux produits pharmaceutiques potentiels pour le traitement de maladies où l'inhibition de PDE7 est utile, en particulier, des maladies inflammatoires, auto-immunes et neurodégénératives. D'autres part, l'invention concerne des composés de la famille des substitués 1,2,4-tiadiazoles-5-imino, ainsi que le procédé permettant de les obtenir, lesquels substitués 1,2,4-tiadiazoles-5-imino peuvent avoir une application large en tant que produits pharmaceutiques ou en tant que produits pharmaceutiques potentiels. Ainsi, un premier aspect de l'invention concerne un composé représenté par la formule (I).