ANTIBODIES BINDING PREFERENTIALLY HUMAN CSF1R EXTRACELLULAR DOMAIN 4 AND THEIR USE

ANTIBODIES BINDING PREFERENTIALLY HUMAN CSF1R EXTRACELLULAR DOMAIN 4 AND THEIR USE

The present invention relates to antibodies against Colony Stimulating Factor-1 Receptor (CSF-1R) (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. CSF-1R contains 5 extracellular domains (ECDs, designated D1-D5), wherein...

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Bibliographische Detailangaben
Hauptverfasser: RIES, CAROLA, SEEBER, STEFAN, DIMOUDIS, NIKOLAOS, FERTIG, GEORG, PICKL, MARLENE, KALUZA, KLAUS, LANZENDOERFER, MARTIN, FIDLER, ALEXANDER
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to antibodies against Colony Stimulating Factor-1 Receptor (CSF-1R) (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. CSF-1R contains 5 extracellular domains (ECDs, designated D1-D5), wherein ECD4 mediates CSF-1R dimerization. Mice were immunized with the extracellular domain of CSF-1R to generate monoclonal antibodies, and antibodies were screened for those that bind only within ECD4. The described antibodies can be used to treat cancer, bone loss, or inflammatory diseases, or to treat or prevent metastasis. La présente invention concerne des anticorps contre CSF-1R humain (anticorps anti-CSF-1R), des procédés pour leur production, des compositions pharmaceutiques contenant lesdits anticorps, et des utilisations de ceux-ci.