MORPHOLINOTHIAZOLES AS ALPHA 7 POSITIVE ALLOSTERIC MODULATORS

The present invention relates to morpholinothiazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to positive allosteric modulators of nicotinic acetylc...

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Bibliographische Detailangaben
Hauptverfasser:	MACDONALD, GREGOR JAMES, DE BOECK, BENOIT CHRISTIAN ALBERT GHISLAIN, LEENAERTS, JOSEPH ELISABETH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to morpholinothiazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulators having the capability to increase the efficacy of nicotinic receptor agonists. Cette invention concerne des dérivés de morpholinothiazoles et des sels pharmaceutiquement acceptables de ces derniers, leurs procédés de fabrication, des compositions pharmaceutiques les renfermant et leur utilisation thérapeutique. L'invention concerne en particulier des modulateurs allostériques de récepteurs nicotiniques de l'acétylcholine tels que des modulateurs allostériques capables d'accroître l'efficacité d'agonistes de récepteurs nicotiniques.