IRE-1.ALPHA. INHIBITORS
The invention provides compounds which directly inhibit IRE-1a activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination the...
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| creator | WADE, WARREN S PATTERSON, JOHN BRUCE ZENG, QINGPING |
| description | The invention provides compounds which directly inhibit IRE-1a activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
Composés inhibant directement l'activité de l'IRE-1a in vitro, des promédicaments et des sels pharmaceutiquement acceptables de ces composés. Des tels composés et promédicaments conviennent pour le traitement de maladies associées à la réponse aux protéines dépliées et peuvent être utilisés comme agents seuls ou dans le cadre de thérapies combinatoires. |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | IRE-1.ALPHA. INHIBITORS |
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