IRE-1.ALPHA. INHIBITORS

IRE-1.ALPHA. INHIBITORS

The invention provides compounds which directly inhibit IRE-1a activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WADE, WARREN S, PATTERSON, JOHN BRUCE, ZENG, QINGPING
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention provides compounds which directly inhibit IRE-1a activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies. Composés inhibant directement l'activité de l'IRE-1a in vitro, des promédicaments et des sels pharmaceutiquement acceptables de ces composés. Des tels composés et promédicaments conviennent pour le traitement de maladies associées à la réponse aux protéines dépliées et peuvent être utilisés comme agents seuls ou dans le cadre de thérapies combinatoires.