ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE

ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE

Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and...

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Bibliographische Detailangaben
Hauptverfasser: PHILLIPS, MARGARET, GUJJAR, RAMESH, CHARMAN, SUSAN A, COTERON-LOPEZ, JOSE, MARWAHA, ALKA, MATTHEWS, DAVID, FLOYD, DAVID, BURROWS, JEREMY, RATHOD, PRADIPSINH K
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts. L'invention concerne des inhibiteurs de l'enzyme parasitaire dihydro-orotate déshydrogénase (DHOD), qui sont des agents thérapeutiques candidats destinés au traitement du paludisme. Un exemple de tels agents thérapeutiques est le composé de formule (...) et une classe de composés de triazolopyrimidine de formule (IX), ainsi que leurs solvates, stéréoisomères, tautomères et sels pharmaceutiquement acceptables.